41.
I am afraid he is burning the candle at both ends.

42.
He has been working on and off for several years on this research project.

43.
He took to heart the death of his wife as he was very much attached to her.

44.
Inspite of his poverty, Ravi believed in keeping up appearances.

45.
He is a strange fellow. It is very difficult to deal with him; it seems that he has a bee in his bonnet.