Immunology in Biotechnology MCQ Questions & Answers

31

A humanized antibody is one in which the

A) Heavy and light chains are from human B) Heavy chain is from human and light chain is from mouse C) Light chain is from human and heavy chain is from mouse D) CDRs are from mouse, and the rest is from human

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Answer & Solution

Answer: Option D

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32

Match the autoimmune diseases in Group I with the corresponding primarily affected organ in Group II.

Group I	Group II
P. Hashimoto's disease	1. Brain
Q. Juvenile diabetes	2. Pancreas
R. Multiple sclerosis	3. Skeletal muscle
S. Myasthenia gravis	4. Thyroid

A) P-1, Q-2, R-3, S-4 B) P-3, Q-1, R-2, S-4 C) P-4, Q-2, R-1, S-3 D) P-1, Q-2, R-4, S-3

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Answer & Solution

Answer: Option C

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33

Which one of the following statements is true with regard to processing and presentation of protein antigens?

A) In the class II MHC pathway, protein antigens in the cytosol are processed by proteasomes B) In the class I MHC pathway, extracellular protein antigens are endocytosed into vesicles and processed C) In the class I MHC pathway, transporter associated antigen processing (TAP) protein is required for translocating processed peptides generated in the cytosol D) Invariant chain in endoplasmic reticulum is involved in transport of peptides and loading of class I MHC

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Answer & Solution

Answer: Option C

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34

Which of the following cytokines are endogenous pyrogens?
P. Tumor necrosis factor α
Q. Interleukin 1
R. Transforming growth factor β
S. Interleukin 10

A) P and Q only B) P and R only C) R and S only D) Q and S only

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Answer & Solution

Answer: Option A

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35

B-lymphocytes originate from the bone marrow, whereas T lymphocytes originate from

A) Thymus B) Bone marrow C) Spleen D) Liver

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Answer & Solution

Answer: Option B

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36

Which of the following conditions promote the development of human autoimmune disorders?
P. Inability to eliminate self-reactive lymphocytes
Q. Generation of auto-antibodies
R. Ability to eliminate self-reactive T cells
S. Induction of regulatory T cells in the thymus

A) P, R B) Q. S C) P, Q D) R, S

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Answer & Solution

Answer: Option C

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37

Which one of the following is not a principal component of innate immunity?

A) Mucosal epithelia B) Dendritic cells C) Complement system D) Memory B cells

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Answer & Solution

Answer: Option D

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38

A neonatally thymectomized mouse, immunized with protein antigen shows

A) Both primary and secondary responses to the antigen B) Only primary response to the antigen C) Delayed type hypersensitive reactions D) No response to the antigen

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Answer & Solution

Answer: Option B

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39

Which of these mice fall to develop a thymus?

A) Motheaten mice B) Beige mice C) Knock out mice D) Nude mice

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Answer & Solution

Answer: Option D

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40

Abzymes are

A) Enzymes that are highly specific like antibodies B) Antibodies that have catalytic activities C) Also, referred to as zymogens D) Enzymes which hydrolyze antibodies

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Answer & Solution

Answer: Option B

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Immunology in Biotechnology MCQ Questions & Answers | Biotechnology