Pyruvic acid, the last product of glycolysis, is degraded to CO₂ and H₂ in

Pyruvic acid, the last product of glycolysis, is degraded to CO₂ and H₂ in the Matrix of mitochondria.
Glycolysis is a cytoplasmic pathway that breaks down glucose into two three-carbon compounds and generates energy.
The final step of glycolysis is catalyzed by pyruvate kinase to form pyruvate and another ATP. During fasting, glucagon activates protein kinase A which phosphorylates pyruvate kinase to inhibit it.