Antonym of VINDICATE

Vindicate : clear (someone) of blame or suspicion.
Exonerate : (of an official body) absolve (someone) from blame for a fault or wrongdoing.
Condemn : sentence (someone) to a particular punishment, especially death.
Defend : resist an attack made on (someone or something); protect from harm or danger.
Excuse : seek to lessen the blame attaching to (a fault or offence); try to justify.

Antonym of Vindicate is Condemn