The fifteenth century witnessed an era of Renaissance in Europe.

Renaissance : the revival of European art and literature under the influence of classical models in the 14th–16th centuries.
Pestilence : a fatal epidemic disease, especially bubonic plague.
Decadence : moral or cultural decline as characterized by excessive indulgence in pleasure or luxury.
Immorality : the state or quality of being immoral; wickedness.
Prehistory : the period of time before written records.

Antonym of Renaissance is Decadence