Which of the following metals causes Itai-Itai disease ?

Itai-itai disease was the documented case of mass cadmium poisoning in Toyama Prefecture, Japan, starting around 1912. The cadmium poisoning caused softening of the bones and kidney failure. The disease is named for the severe pains caused in the joints and spine. The cadmium was released into rivers by mining companies in the mountains. The mining companies were successfully sued for the damage. Itai-itai disease is known as one of the Four Big Pollution Diseases of Japan. Itai-itai disease was caused by cadmium poisoning due to mining in Toyama Prefecture. The cadmium and other heavy metals accumulated at the bottom of the river and in the water of the river. This water was then used to irrigate the rice fields. The rice absorbed heavy metals, especially the cadmium. The cadmium accumulated in the people eating contaminated rice.