During differentiation, cells with the same DNA

During differentiation, cells with the same DNA May transcribe different genes.
The cell types in a multicellular organism become different from one another because they synthesize and accumulate different sets of RNA and protein molecules. They generally do this without altering the sequence of their DNA.
During the differentiation of pluripotent cells such as embryonic stem (ES) cells, pluripotency-associated genes are repressed, potentially permanently, as a result of DNA methylation.