The stratospheric ozone layer plays an important protective role for life on earth and its disruption is obviously fraught with dangerous consequences.

Involving : have or include (something) as a necessary or integral part or result.
Concerned : worried, troubled, or anxious.
Followed : go or come after (a person or thing proceeding ahead); move or travel behind.
Caused : make (something, especially something bad) happen.
Fraught : (of a situation or course of action) filled with or likely to result in (something undesirable).

Synonym of Fraught is Involving