Consider the following statements regarding self-assembly and choose the correct answer:
1. Modern self-assembly theory holds that protobiogenesis occurred due to inherent property of chemical molecules of self organization
2. First clear cut demonstration of self-assembly was provided by Schmitt (1956)
3. The combination of proteins and nucleic acids, as in tobacco mosaic virus, is an example of intermacromolecular assembly
4. The modern researches of protobiogenesis by self-assembly challenge the central dogma of molecular biology suggested by Watson (1965)