In Access to open new database press

To open a new database in Microsoft Access, you can use the keyboard shortcut CTRL+N. This combination of keys will create a new, blank database. It's important to note that CTRL+O is typically used to open an existing database, not to create a new one. ALT+F4 is a general Windows shortcut to close the currently active window, and it would not be used to open a new database. Therefore, the correct option is Option A: CTRL+N.