Rate limiting enzyme in cholesterol biosynthesis

A. α 1-4 glucosidase

B. HMG-CoA reductase

C. Squalene synthetase

D. 7 α-hydroxylase

Answer: Option B

Solution(By Examveda Team)

Rate limiting enzyme in cholesterol biosynthesis is HMG-CoA reductase.
The biosynthetic pathway of cholesterol proceeds through several intermediates and involves different enzymes.
The rate-limiting step of cholesterol synthesis is the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that synthesizes mevalonate starting from HMG-CoA.