Substance responsible for increase penetration of Lyssa virus

Substance responsible for increased penetration of Lyssa virus is Hyaluronidase.
Hyaluronidase is an enzyme that breaks down a substance in the body called hyaluronic acid. Hyaluronic acid is found throughout the body in connective tissue, skin, and fluids in the joints and inside the eye.
Lyssavirus is a genus of RNA viruses in the family Rhabdoviridae that are enveloped, with bullet-shaped geometries. These virions are about 75 nm wide and 180 nm long. Lyssavirions have helical symmetry, so their infectious particles are approximately cylindrical. This is typical of plant-infecting viruses.