Molecular Biology and Genetics MCQ Questions & Answers

21

A protein is phosphorylated at a serine residue. A phosphomimic mutant of the protein can be generated by substituting that serine with

A) Glycine B) Alanine C) Aspartate D) Threonine

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Answer & Solution

Answer: Option C

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22

Under alkaline conditions, DNA is more stable than RNA because

A) RNA forms secondary structures B) RNA is a single stranded molecule C) RNA has uracil in place of thymidine D) RNA is susceptible to hydrolysis

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Answer & Solution

Answer: Option D

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23

True breeding Drosophila flies with curved wings and dark bodies were mated with true breeding short wings and tan body Drosophila, The F₁ progeny was observed to be with curved wings and tan body. The F₁ progeny was again allowed to breed and produced flies of the following phenotype, 45 curved wings tan body, 15 short wings tan body, 16 curved wings dark body and, 6 short wings dark body. The mode of inheritance is

A) Typical Mendelian with curved wings and tan body being dominant B) Typical non-Mendelian with curved wings and tan body not following any pattern C) Mendelian with suppression of phenotypes D) Mendelian with single crossover

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Answer & Solution

Answer: Option A

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24

The enzyme which adds phosphate group to the free 5' terminus of a DNA sequence is

A) Adenosine kinase B) Alkaline phosphatase C) Polynucleotide kinase D) Terminal deoxynucleotidyl transferase

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Answer & Solution

Answer: Option C

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25

The fundamental feature of the genetic code which allows the expression of a protein in any host is its

A) Triplet nature B) Universality C) Degeneracy D) Redundancy

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Answer & Solution

Answer: Option B

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26

Match the terms in Group I with their possible explanation in Group II

Group I	Group II
P. Orthologs	1. A cell or an organism, having foreign gene
Q. Paralogs	2. The complement of a protein expressed by a genome
R. Proteome	3. Genes from different species related to each other
S. Transgenic	4. Genes from same species related to each other

A) P-2, Q-4, R-1, S-3 B) P-4, Q-3, R-2, S-1 C) P-3, Q-4, R-2, S-1 D) P-1, Q-2, R-3, S-4

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Answer & Solution

Answer: Option B

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27

Which one of the following amino acids in proteins does not undergo phosphorylation?

A) Ser B) thr C) Pro D) Tyr

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Answer & Solution

Answer: Option C

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28

In eukaryotes, the ribosomal RNA genes are transcribed by

A) Reverse transcriptase B) RNA dependent RNA polymerase C) RNA polymerase I D) RNA polymerase III

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Answer & Solution

Answer: Option C

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29

The repeat sequence of telomere in humans is

A) 5'-TATAAT-3' B) 5'-TTAGGG-3' C) 5'-GGGCCC-3' D) 5'-AAAAAA-3'

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Answer & Solution

Answer: Option B

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30

Match the terms in Group I with their associated functions in Group II.

Group I	Group II
P. Shine-Dalgarno sequences	1. Aminoacylation of tRNA
Q. Leucine zipper	2. Gene silencing
R. Aminoacyl tRNA synthetase	3. Ribosome binding and facilitation of translation initiation
S. RNA interference (RNAi)	4. Transcription factors

A) P-3, Q-4, R-1, S-2 B) P-4, Q-3, R-2, S-1 C) P-2, Q-3, R-1, S-4 D) P-3, Q-4, R-4, S-1

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Answer & Solution

Answer: Option A

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Molecular Biology and Genetics MCQ Questions & Answers | Biotechnology