Molecular Biology and Genetics MCQ Questions & Answers

61.
A mutation in a gene that codes for a polypeptide results in a variant polypeptide that lacks the last three amino acids. What type of mutation is this?

A. Synonymous mutation

B. Nonsense mutation

C. Missense mutation

D. Silent mutation

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62.
Match the entries in Group I with the entries in Group II.

Group I Group II

P. RNAse P 1. Polyadenylation

Q. RNase H 2. Splicing

R. snRNAs 3. Ribozymes

S. CstF 4. DNA-RNA hybrids

A. P-3, Q-4, R-2, S-1

B. P-4, Q-3, R-2, S-1

C. P-3, Q-2, R-1, S-4

D. P-2, Q-4, R-1, S-3

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63.
Topological winding number of a 2.0 kb covalently closed circular DNA was found to be 191 with a writhing number of -4. Hence, its linking number and the number of base pair per turn when the molecule is laid flat on the surface is . . . . . . . . and . . . . . . . ., respectively.

A. 187, 10.69

B. 195, 10.25

C. 200, 10.00

D. 187, 10.50

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64.
PKU is one of the best-known hereditary disorders in amino acid metabolism. The defect is attributed to a lesion in one of the following enzymatic activities:

A. Phenylalanine ammonia lyase

B. Phenylalanine hydroxylase

C. Tyrosine hydroxylase

D. Phenylalanine transaminase

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65.
A truncated polypeptide is synthesized due to a nonsense mutation. Where would you introduce another mutation to obtain a full-length polypeptide?

A. Ribosomal protein gene

B. Transfer RNA gene

C. DNA repair gene

D. Ribosomal RNA gene

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66.
Diploid Drosophila has eight chromosomes. Which one of the following terms should not be used to describe Drosophila with sixteen numbers of chromosomes?

A. Polyploid

B. Aneuploid

C. Euploid

D. Tetraploid

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67.
How many 3-tuples are possible for the following amino acid sequence?

A. 4

B. 5

C. 11

D. 12

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68.
Molecular chaperones are class of proteins that facilitate

A. The proper folding of newly synthesized proteins

B. Unfolding of newly synthesized proteins

C. Degradation of newly synthesized proteins

D. Targeting of newly synthesized proteins

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69.
Which one of the following is not a therapeutic agent based on nucleic acid for the treatment of genetic disorders?

A. Antisense oligonucleotide

B. Ribozyme

C. Aptamer

D. Avidin

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70.
The enzyme that transcribes the eukaryotic genes encoding precursor ribosomal RNAs (pre-rRNAs) of 28S, 18S and 5.8S rRNAs is

A. RNA polymerase I

B. RNA polymerase II

C. RNA polymerase III

D. RNA polymerase IV

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Group I	Group II
P. RNAse P	1. Polyadenylation
Q. RNase H	2. Splicing
R. snRNAs	3. Ribozymes
S. CstF	4. DNA-RNA hybrids

Molecular Biology and Genetics MCQ Questions & Answers | Biotechnology

61. A mutation in a gene that codes for a polypeptide results in a variant polypeptide that lacks the last three amino acids. What type of mutation is this?

Answer & Solution

62. Match the entries in Group I with the entries in Group II. Group I Group II P. RNAse P 1. Polyadenylation Q. RNase H 2. Splicing R. snRNAs 3. Ribozymes S. CstF 4. DNA-RNA hybrids

Answer & Solution

63. Topological winding number of a 2.0 kb covalently closed circular DNA was found to be 191 with a writhing number of -4. Hence, its linking number and the number of base pair per turn when the molecule is laid flat on the surface is . . . . . . . . and . . . . . . . ., respectively.

Answer & Solution

64. PKU is one of the best-known hereditary disorders in amino acid metabolism. The defect is attributed to a lesion in one of the following enzymatic activities:

Answer & Solution

65. A truncated polypeptide is synthesized due to a nonsense mutation. Where would you introduce another mutation to obtain a full-length polypeptide?

Answer & Solution

66. Diploid Drosophila has eight chromosomes. Which one of the following terms should not be used to describe Drosophila with sixteen numbers of chromosomes?

Answer & Solution

67. How many 3-tuples are possible for the following amino acid sequence?

Answer & Solution

68. Molecular chaperones are class of proteins that facilitate

Answer & Solution

69. Which one of the following is not a therapeutic agent based on nucleic acid for the treatment of genetic disorders?

Answer & Solution

70. The enzyme that transcribes the eukaryotic genes encoding precursor ribosomal RNAs (pre-rRNAs) of 28S, 18S and 5.8S rRNAs is

Answer & Solution

61.
A mutation in a gene that codes for a polypeptide results in a variant polypeptide that lacks the last three amino acids. What type of mutation is this?

62.
Match the entries in Group I with the entries in Group II.

Group I Group II

P. RNAse P 1. Polyadenylation

Q. RNase H 2. Splicing

R. snRNAs 3. Ribozymes

S. CstF 4. DNA-RNA hybrids

63.
Topological winding number of a 2.0 kb covalently closed circular DNA was found to be 191 with a writhing number of -4. Hence, its linking number and the number of base pair per turn when the molecule is laid flat on the surface is . . . . . . . . and . . . . . . . ., respectively.

64.
PKU is one of the best-known hereditary disorders in amino acid metabolism. The defect is attributed to a lesion in one of the following enzymatic activities:

65.
A truncated polypeptide is synthesized due to a nonsense mutation. Where would you introduce another mutation to obtain a full-length polypeptide?

66.
Diploid Drosophila has eight chromosomes. Which one of the following terms should not be used to describe Drosophila with sixteen numbers of chromosomes?

67.
How many 3-tuples are possible for the following amino acid sequence?

68.
Molecular chaperones are class of proteins that facilitate

69.
Which one of the following is not a therapeutic agent based on nucleic acid for the treatment of genetic disorders?

70.
The enzyme that transcribes the eukaryotic genes encoding precursor ribosomal RNAs (pre-rRNAs) of 28S, 18S and 5.8S rRNAs is