. . . . . . . . great improvement in . . . . . . . . patients condition was brought about by . . . . . . . . use of . . . . . . . . newly developed antibiotic.

A. no article, the, no article, a

B. a, the, no article, no article

C. the, the, no article, no article

D. a, the, the, a

Answer: Option D

Solution(By Examveda Team)

The first blank shall take 'a' as 'great improvement' is an expression of quantity. The second and third blank shall take 'the' as the sentence talks about a particular set of patients taking a particular antibiotic. The fourth blank shall take 'a' as 'newly developed antibiotic' represents a singular countable noun and is followed by a word starting with the consonant sound.